Brazilian Journal of Veterinary Research and Animal Science
On-line version ISSN 1678-4456
MORAES, Julieta Rodini Engrácia de; MORAES, Flávio Ruas de and ENGRACIA FILHO, Jair Rodini. Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats. Braz. J. Vet. Res. Anim. Sci. [online]. 1998, vol.35, n.6, pp. 00-00. ISSN 1678-4456. http://dx.doi.org/10.1590/S1413-95961998000600002.
We investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mg) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after the carrageenin-injection.
Keywords : Chloramphenicol; Diabetes; Pleurisia; Neutrophils.