Resumo

MOLLER, Vanessa Maraschin et al. Effects of the endectocid ivermectin (Ivomec(r) 1% injection) on pregnants females wistar rats. Braz. J. Vet. Res. Anim. Sci. [online]. 2003, vol.40, n.5, pp. 328-333. ISSN 1413-9596.  http://dx.doi.org/10.1590/S1413-95962003000500003.

In order to evaluate the possible effect of ivermectin used on pregnant animals, Wistar rats were treated orally on sixth pregnancy day, with dosage of 20 and 60 times higher than therapeutic dosage used to treat scabiosis in dogs and cats. During all pregnant period, body weight, water and pellet food consuption of dams were determined. The dams were sacrificed at term for the evaluation of maternal and fetal parameters. The numbers of corporea lutea, post implantation loss and living and death fetuses were recorded. Also the organs of dams were removed, weighted and histopatologically examined. Fetuses were weighted, sexed, examined for external macroscopic malformations. Results showed absence of systemic and reproductive toxicity. It is concluded that ivermectin is no toxic to the dams and fetus, when administered in the beginning of organogenic period.

Palavras-chave : Ivermectin; Toxicity.