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Genetics and Molecular Biology

On-line version ISSN 1678-4685


PASSOS JR., Geraldo A.S.. Physical map and one-megabase sequencing of the human immunoglobulin lambda locus. Genet. Mol. Biol. [online]. 1998, vol.21, n.2, pp. 281-286. ISSN 1678-4685.

The human immunoglobulin lambda (IGL) locus is located on chromosome 22q11.1-q11.2 and contains the genes responsible for the immunoglobulin lambda light chains. This locus was recently mapped (physical map) and its 1-Mb DNA totally sequenced. In this review we focus on the characterization of the v-lambda genes, its chromosomal location, genomics and sequencing of the IGL locus.

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