Genetics and Molecular Biology
On-line version ISSN 1678-4685
PASSOS JR., Geraldo A.S.. Physical map and one-megabase sequencing of the human immunoglobulin lambda locus. Genet. Mol. Biol. [online]. 1998, vol.21, n.2, pp.281-286. ISSN 1678-4685. http://dx.doi.org/10.1590/S1415-47571998000200019.
The human immunoglobulin lambda (IGL) locus is located on chromosome 22q11.1-q11.2 and contains the genes responsible for the immunoglobulin lambda light chains. This locus was recently mapped (physical map) and its 1-Mb DNA totally sequenced. In this review we focus on the characterization of the v-lambda genes, its chromosomal location, genomics and sequencing of the IGL locus.