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Genetics and Molecular Biology

Print version ISSN 1415-4757On-line version ISSN 1678-4685

Abstract

FERREIRA, Francileide Lisboa; LEAL-MESQUITA, Emygdia Rosa; SANTOS, Sidney Emanuel Batista dos  and  RIBEIRO-DOS-SANTOS, Ândrea Kely Campos. Genetic characterization of the population of São Luís, MA, Brazil. Genet. Mol. Biol. [online]. 2005, vol.28, n.1, pp.22-31. ISSN 1415-4757.  http://dx.doi.org/10.1590/S1415-47572005000100004.

Five loci (vWA1, F13A1, D12S67, Apo-B and D1S80) were investigated by polyacrylamide gel electrophoresis followed by silver staining in a sample of 177 individuals from the population of São Luís, State of Maranhão, Brazil. A total of 70 different alleles were identified. A statistically significant deviation from the Hardy-Weinberg equilibrium was observed in a single locus (F13A1, p = 0.0075). The average heterozygosity (H) was estimated at 77.7%, the mean number of alleles per locus as 14. The PD (capacity of genotype differentiation at each locus) ranged from 88.9% (vWA1) to 96.7% (F13A1). The combined PE (power of exclusion) of these five loci was 99.8%. In terms of racial admixture (42% European, 39% Indian, and 19% African Black ancestry), São Luís presented an estimate similar to Belém, another trihybrid Amazonian population.

Keywords : Amazon region; DNA; polymorphisms; VNTRs; STRs; interethnic admixture.

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