Genetics and Molecular Biology
Print version ISSN 1415-4757
KLAUTAU-GUIMARAES, Maria de Nazaré et al. Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians. Genet. Mol. Biol. [online]. 2005, vol.28, n.1, pp. 32-35. ISSN 1415-4757. http://dx.doi.org/10.1590/S1415-47572005000100005.
The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missão Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0% for GSTM1 and 27% for GSTT1 while for the Kayabi sample the null phenotype frequencies were 27% for GSTM1 and 29% for GSTT1. This is the first report of the absence of the GSTM1 null phenotype in any ethnic group.
Keywords : Munduruku; glutathione S-transferase; Kayabi; null alleles.