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Genetics and Molecular Biology
On-line version ISSN 1678-4685
VINOCUR, Myriam E. et al. Equine protease inhibitor system as a marker for the diagnosis of chronic obstructive pulmonary disease (COPD). Genet. Mol. Biol. [online]. 2005, vol.28, n.3, pp. 382-385. ISSN 1678-4685. http://dx.doi.org/10.1590/S1415-47572005000300007.
The protease inhibitor system (PI) was investigated to ascertain if it can be used as a marker of chronic obstructive pulmonary disease (COPD) in thoroughbred horses. Serum samples were taken from healthy thoroughbreds (n = 13) and those diagnosed as having COPD (n = 24) or inflammatory airway disease (IAD, n = 38) as well as from 3,600 undiagnosed thoroughbred horses. PI allelic and genotypic frequencies were estimated using protein electrophoresis on starch and polyacrylamide gels. The four groups of horses showed high genotypic similarity and none of the observed alleles or genotypes of the equine PI system were found to be associated with COPD.
Keywords : horse; chronic obstructive pulmonary disease; protease inhibitor system.