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Genetics and Molecular Biology
On-line version ISSN 1678-4685
STARK, Alan E.. On extending the Hardy-Weinberg law. Genet. Mol. Biol. [online]. 2007, vol.30, n.3, pp. 664-666. ISSN 1678-4685. http://dx.doi.org/10.1590/S1415-47572007000400026.
This paper gives a general mating system for an autosomal locus with two alleles. The population reproduces in discrete and non-overlapping generations. The parental population, the same in both sexes, is arbitrary as is that of the offspring and the gene frequencies of the parents are maintained in the offspring. The system encompasses a number of special cases including the random mating model of Weinberg and Hardy. Thus it demonstrates, in the most general way possible, how genetic variation can be conserved in an indefinitely large population without invoking random mating or balancing selection. An important feature is that it provides a mating system which identifies when mating does and does not produce Hardy-Weinberg proportions among offspring.
Keywords : Hardy-Weinberg law; non-random mating; general offspring distribution.