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Genetics and Molecular Biology
On-line version ISSN 1678-4685
BARBOSA, Cynara Gomes et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genet. Mol. Biol. [online]. 2008, vol.31, n.1, pp. 29-32. ISSN 1678-4685. http://dx.doi.org/10.1590/S1415-47572008000100005.
Methylenetetrahydrofolate reductase (MTHFR: EC 188.8.131.52) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3.
Keywords : AML; CML; MTHFR polymorphisms.