Genetics and Molecular Biology
Print version ISSN 1415-4757
ALVES, Alexandre Alonso; BHERING, Leonardo Lopes; CRUZ, Cosme Damião and ALFENAS, Acelino Couto. Linkage analysis between dominant and co-dominant makers in full-sib families of out-breeding species. Genet. Mol. Biol. [online]. 2010, vol.33, n.3, pp. 499-506. ISSN 1415-4757. http://dx.doi.org/10.1590/S1415-47572010000300021.
As high-throughput genomic tools, such as the DNA microarray platform, have lead to the development of novel genotyping procedures, such as Diversity Arrays Technology (DArT) and Single Nucleotide Polymorphisms (SNPs), it is likely that, in the future, high density linkage maps will be constructed from both dominant and co-dominant markers. Recently, a strictly genetic approach was described for estimating recombination frequency (r) between co-dominant markers in full-sib families. The complete set of maximum likelihood estimators for r in full-sib families was almost obtained, but unfortunately, one particular configuration involving dominant markers, segregating in a 3:1 ratio and co-dominant markers, was not considered. Here we add nine further estimators to the previously published set, thereby making it possible to cover all combinations of molecular markers with two to four alleles (without epistasis) in a full-sib family. This includes segregation in one or both parents, dominance and all linkage phase configurations.
Keywords : statistical genomics; exogamic populations; recombination frequency and maximum likelihood.