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Genetics and Molecular Biology

Print version ISSN 1415-4757


SILVA, Aline Correa da et al. Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses. Genet. Mol. Biol. [online]. 2011, vol.34, n.3, pp.456-458.  Epub June 17, 2011. ISSN 1415-4757.

The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.

Keywords : horse; respiratory disease; SSCP; alpha-1-antitrypsin; serpin.

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