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Genetics and Molecular Biology

Print version ISSN 1415-4757

Abstract

XIAO, Jing  and  YIQING, Qiu. Bioinformatics analysis of the gene expression profile in Bladder carcinoma. Genet. Mol. Biol. [online]. 2013, vol.36, n.2, pp.287-291.  Epub Apr 12, 2013. ISSN 1415-4757.  https://doi.org/10.1590/S1415-47572013005000015.

Bladder carcinoma, which has the ninth highest incidence among malignant tumors in the world, is a complex, multifactorial disease. The malignant transformation of bladder cells results from DNA mutations and alterations in gene expression levels. In this work, we used a bioinformatics approach to investigate the molecular mechanisms of bladder carcinoma. Biochips downloaded from the Gene Expression Omnibus (GEO) were used to analyze the gene expression profile in urinary bladder cells from individuals with carcinoma. The gene expression profile of normal genomes was used as a control. The analysis of gene expression revealed important alterations in genes involved in biological processes and metabolic pathways. We also identified some small molecules capable of reversing the altered gene expression in bladder carcinoma; these molecules could provide a basis for future therapies for the treatment of this disease.

Keywords : Bladder carcinoma; differential expression; expression profile; small molecular mimic; susceptibility forecast.

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