UK Caucasian |
29-35 |
1619 |
1158 (71.5) |
409 (25.3) |
52 (3.2) |
- |
84.2 |
15.8 |
- |
Freathy et al., 2006Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT and Frayling TM (2006) The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet 7:e51.
|
Bohemian Czech |
New Born |
390 |
307 (78.7) |
73 (18.7) |
10 (2.6) |
0.016 |
88.1 |
11.9 |
0.006 |
Arking et al., 2003Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF, Becker LC and Dietz HC (2003) KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 72:1154-1161.
|
|
Elderly ≥ 75 |
415 |
308 (74.2) |
103 (24.8) |
4 (0.1) |
0.040 |
86.6 |
13.4 |
0.078 |
|
Baltimore Caucasian |
New Born |
420 |
309 (73.6) |
100 (23.8) |
11 (2.6) |
0.652 |
85.5 |
14.5 |
0.347 |
|
|
Elderly ≥ 65 |
723 |
530 (73.3) |
185 (25.6) |
8 (1.1) |
0.012 |
86.1 |
13.9 |
0.088 |
|
Baltimore African American |
New Born |
226 |
156 (69.0) |
58 (25.7) |
12 (5.3) |
0.259 |
81.9 |
18.1 |
0.213 |
|
Elderly ≥ 65 |
242 |
169 (69.8) |
68 (28.1) |
5 (2.1) |
0.439 |
83.9 |
16.1 |
0.878 |
|
American |
Mean 54.3 |
143 |
95 (66.4) |
44 (30.8) |
4 (2.8) |
0.350 |
81.8 |
18.2 |
0.302 |
Low et al., 2005Low AF, O'Donnell CJ, Kathiresan S, Everett B, Chae CU, Shaw SY, Ellinor PT and MacRae CA (2005) Aging syndrome genes and premature coronary artery disease. BMC Med Genet 6:e38.
|
US Caucasian |
<35 |
332 |
241 (72.6) |
85 (25.6) |
6 (1.8) |
0.390 |
85.4 |
14.6 |
0.425 |
Novelli et al., 2008Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G and Puca AA (2008) Lack of replication of genetic associations with human longevity. Biogerontology 9:85-92.
|
|
93-105 |
708 |
517 (73.0) |
170 (24.0) |
21 (3.0) |
0.757 |
85.0 |
15.0 |
0.451 |
|
Spanish |
18-86 (mean 48.0) |
438 |
330 (75.3) |
104 (23.8) |
4 (0.9) |
0.021 |
87.2 |
12.8 |
0.025 |
Riancho et al., 2007Riancho JA, Valero C, Hernández JL, Ortiz F, Zarrabeitia A, Alonso MA, Peña N, Pascual MA, González-Macías J and Zarrabeitia MT (2007) Association of the F352V variant of the Klotho gene with bone mineral density. Biogerontology 8:121-127.
|
Greek |
Men (mean 61.5), Women (mean 65.8) |
383 |
309 (80.7) |
71 (18.4) |
3 (0.8) |
<0.001 |
90.0 |
10.0 |
<0.001 |
Tsezou et al., 2008Tsezou A, Furuichi T, Satra M, Makrythanasis P, Ikegawa S and Malizos KN (2008) Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population. J Orthop Res 26:1466-1670.
|
Italian |
Men <66, Women <73 |
463 |
348 (75.2) |
103 (22.2) |
12 (2.6) |
0.300 |
86.3 |
13.7 |
0.113 |
Invidia et al., 2010Invidia L, Salvioli S, Altilia S, Pierini M, Panourgia MP, Monti D, De Rango F, Passarino G and Franceschi C (2010) The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect. Biogerontology 11:67-73.
|
|
Men 66-88, Women 73-91 |
300 |
203 (67.7) |
94 (31.3) |
3 (1.0) |
0.140 |
83.3 |
16.7 |
0.613 |
|
|
Men >88, Women >91 |
326 |
236 (72.4) |
80 (24.5) |
10 (3.1) |
0.950 |
84.7 |
15.3 |
0.746 |
|
French |
25-88 (mean 57.5) |
629 |
436 (69.3) |
172 (27.4) |
21 (3.3) |
0.579 |
83.0 |
17.0 |
0.340 |
Nzietchueng et al., 2011Nzietchueng RE, Shamieh S, Benachour H, Labat C, Herbeth B, Ndiaye NC, Masson C, Visvikis-Siest S and Benetos A (2011) Klotho KL-VS genotype is involved in blood pressure regulation. Clin Chim Acta 412:1773-1777.
|
Iranian |
Mean 55 |
53 |
53 (100) |
0 (0) |
0 (0) |
<0.001 |
100 |
0 |
<0.001 |
Tavakkoly-Bazzaz et al., 2011Tavakkoly-Bazzaz J, Tabatabaei-Malazy O, Tajmir-Riahi M, Javidi D, Izadi M, Shahrabi-Farahani M, Amiri P and Amoli MM (2011) Absence of kl-vs variant of klotho gene in Iranian cardiac patients (comparison to the world populations). Dis Markers 31:211-214.
|
Indian |
≤ 40 |
375 |
270 (72.0) |
99 (26.4) |
6 (1.6) |
0.237 |
85.2 |
14.8 |
0.479 |
Majumdar et al., 2010Majumdar V, Nagaraja D and Christopher R (2010) Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke. Biochem Biophys Res Commun 403:412-416.
|
|
>40 |
199 |
140 (70.4) |
53 (26.6) |
6 (3.0) |
0.911 |
83.7 |
16.3 |
0.801 |
|
Korean |
≤ 40 (mean 27.0) |
101 |
101 (100) |
0 (0) |
0 (0) |
<0.001 |
100 |
0 |
<0.001 |
This study |
|
40-79 (mean 62.9) |
671 |
671 (100) |
0 (0) |
0 (0) |
<0.001 |
100 |
0 |
<0.001 |
|
|
≥ 80 (mean 85.8) |
102 |
102 (100) |
0 (0) |
0 (0) |
<0.001 |
100 |
0 |
<0.001 |
|