Colon carcinoma (Yagublu et al., 2011Yagublu V, Arthur JR, Babayeva SN, Nicol F, Post S and Keese M (2011) Expression of selenium-containing proteins in human colon carcinoma tissue. Anticancer Res 31:2693-2698.) |
↑ |
↑ |
- |
- |
- |
- |
- |
- |
- |
Colorectal cancer (Hughes et al., 2018Hughes DJ, Kunická T, Schomburg L, Liška V, Swan N and Souček P (2018) Expression of selenoprotein genes and association with selenium status in colorectal adenoma and colorectal cancer. Nutrients 10:1812.) |
↑ |
NS |
- |
↓ |
- |
↑ |
- |
- |
- |
Bladder cancer (Wieczorek et al., 2017Wieczorek E, Jablonowski Z, Tomasik B, Gromadzinska J, Jablonska E, Konecki T, Fendler W, Sosnowski M, Wasowicz W and Reszka E (2017) Different gene expression and activity pattern of antioxidant enzymes in bladder cancer. Anticancer Res 37:841-848.) |
↑ |
- |
- |
- |
- |
NS |
- |
NS |
- |
Laryngeal squamous cell carcinoma (Zhang et al., 2018Zhang Q, Xu H, You Y, Zhang J and Chen R (2018) High Gpx1 expression predicts poor survival in laryngeal squamous cell carcinoma. Auris Nasus Larynx 45:170-174.) |
↑ |
- |
- |
- |
- |
- |
- |
- |
- |
Gastric Cancer (Lan et al., 2017Lan X, Xing J, Gao H, Li S, Quan L, Jiang Y, Ding S and Xue Y (2017) Decreased expression of selenoproteins as a poor prognosticator of gastric cancer in humans. Biol Trace Elem Res 178:22-28.) |
↓ |
↓ |
↓ |
- |
- |
- |
- |
- |
- |
Clear cell renal cell carcinomas (Rudenko et al., 2015Rudenko E, Kondratov O, Gerashchenko G, Lapska Y, Kravchenko S, Koliada O, Vozianov S, Zgonnyk Y and Kashuba V (2015) Aberrant expression of selenium-containing glutathione peroxidases in clear cell renal cell carcinomas. Exp Oncol 37:105-110.) |
↓ |
↓ |
- |
- |
- |
- |
- |
- |
- |
Clear cell renal cell carcinomas (Cheng et al., 2019Cheng Y, Xu T, Li S and Ruan H (2019) GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer. Aging (Albany NY) 11:12165-12176.) |
↑ |
NS |
- |
- |
- |
- |
- |
- |
- |
Breast Cancer (Król et al., 2018Król MB, Galicki M, Grešner P, Wieczorek E, Jablonska E, Reszka E, Morawiec Z, Wasowicz W and Gromadzinska J (2018) The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues. Acta Biochim Pol 65:51-57.) |
↓ |
- |
- |
- |
- |
- |
- |
- |
- |
Breast Cancer (Wolf et al., 2016Wolf B, Goebel G, Hackl H and Fiegl H (2016) Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients. BMC Cancer 16:1-14.) |
- |
- |
- |
- |
- |
- |
- |
- |
↓ |
MCF 7 cells (Rusolo et al., 2017Rusolo F, Capone F, Pasquale R, Angiolillo A, Colonna G, Castello G, Costantini M and Costantini S (2017) Comparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell lines. Oncol Lett 13:2411-2417.) |
↓ |
↓ |
- |
- |
- |
- |
- |
- |
- |
MCF 7 cells (Shi et al., 2017Shi Y, Ye P and Long X (2017) Differential expression profiles of the transcriptome in breast cancer cell lines revealed by next generation sequencing. Cell Physiol Biochem 44:804-816.) |
- |
- |
- |
- |
- |
↑ |
- |
- |
- |
Non-small cell lung cancer (Gresner et al., 2009Gresner P, Gromadzinska J, Jablonska E, Kaczmarski J and Wasowicz W (2009) Expression of selenoprotein-coding genes SEPP1, SEP15 and hGPX1 in non-small cell lung cancer. Lung Cancer 65:34-40.) |
- |
- |
NS |
↓ |
- |
- |
- |
- |
- |
Lung squamous cell carcinoma (Zhang et al., 2016Zhang Y, Fan H, Fang S, Wang L, Chen L, Jin Y, Jiang W, Lin Z, Shi Y, Zhan C et al. (2016) Mutations and expression of the NFE2L2/KEAP1/CUL3 pathway in Chinese patients with lung squamous cell carcinoma. J Thorac Dis 8:1639-1644.) |
- |
- |
- |
- |
- |
- |
- |
- |
↑ |
Oral squamous cell carcinoma (Pedro et al., 2018Pedro NF, Biselli JM, Maniglia JV, Santi-Neto D, Pavarino ÉC, Goloni-Bertollo EM and Biselli-Chicote PM (2018) Candidate biomarkers for oral squamous cell carcinoma: differential expression of oxidative stress-related genes. Asian Pacific J Cancer Prev 19:1343-1349.) |
- |
- |
- |
- |
↓ |
↑ |
↓ |
↓ |
- |
Hepatocellular carcinoma (Wang et al., 2016Wang Z, Li Z, Ye Y, Xie L and Li W (2016b) Oxidative stress and liver cancer: Etiology and therapeutic targets. Oxid Med Cell Longev 2016:7891574.) |
- |
- |
- |
- |
- |
↓ |
- |
- |
- |
Hepatocellular carcinoma (Guerriero et al., 2015Guerriero E, Capone F, Accardo M, Sorice A, Costantini M, Colonna G, Castello G and Costantini S (2015) GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues. Eur J Histochem 59:5-10.) |
- |
↑ |
- |
- |
- |
- |
- |
- |
- |
Hepatocellular carcinoma (Cheng et al., 2015Cheng ML, Lu YF, Chen H, Shen ZY and Liu J (2015) Liver expression of Nrf2-related genes in different liver diseases. Hepatobiliary Pancreat Dis Int 14:485-491.) |
- |
- |
- |
- |
- |
- |
- |
- |
↑ |
HepG2 cell line (Zhao et al., 2015Zhao H, Tang J, Xu J, Cao L, Jia G, Long D, Liu G, Chen X and Wang K (2015) Selenoprotein genes exhibit differential expression patterns between hepatoma HepG2 and normal hepatocytes LO2 cell lines. Biol Trace Elem Res 167:236-241.) |
↑ |
↑ |
- |
↑ |
- |
- |
- |
- |
- |
HepG2 and Huh7 cell lines (Guariniello et al., 2015Guariniello S, Di Bernardo G, Colonna G, Cammarota M, Castello G and Costantini S (2015) Evaluation of the selenotranscriptome expression in two hepatocellular carcinoma cell lines. Anal Cell Pathol (Amst) 2015:419561.) |
- |
↑ |
↑ |
- |
- |
- |
- |
- |
- |
TCGA (Tumor x normal adjacent tissue) |
↑ |
NS |
NS |
↓ |
↓ |
↓ |
NS |
↓ |
↓ |
TCGA x GTEx (Case x control) |
↑ |
↑ |
↑ |
↑ |
NS |
↓ |
↑ |
↓ |
↑ |
ISCMPA (Tumor x peritumor) |
NS |
↑ |
NS |
NS |
NS |
↑ |
NS |
NS |
NS |