Revista de Nutrição
Print version ISSN 1415-5273
FIALHO, Eliane; MORENO, Fernando Salvador and ONG, Thomas Prates. Nutrition in the post-genome era: 'omic' tools basics and applications. Rev. Nutr. [online]. 2008, vol.21, n.6, pp. 757-766. ISSN 1415-5273. http://dx.doi.org/10.1590/S1415-52732008000600014.
After sequencing the human genome, genomic studies have been focusing on elucidating the function of all genes, as well as characterizing their interactions with environmental factors. Nutrigenomics emerged in the pos-genome era and is considered a key-area for nutrition in the present decade. Its research focus is nutrient-gene interaction. The main objective of this recent science is to establish personalized genotype-based diets that promote health and reduce the risk of non-communicable chronic diseases such as cardiovascular diseases, cancer, diabetes and others. In this context, it is essential to use functional genomic tools to analyze the transcriptome (transcriptomics), proteome (proteomics) and metabolome (metabolomics) in the field of nutrition. The applicabilities of such methodologies in nutritional studies seem unlimited since they can be conducted in cell cultures, animal models and pre-clinical and clinical studies. Such techniques may allow one to identify biomarkers that respond specifically to a certain dietary nutrient or bioactive compound and to establish the best individual dietary advice to reduce the risk of non-communicable chronic diseases and promote health.
Keywords : Nutrition public health; Nutrigenomics; Transcriptomics; Proteomics.