Revista de Nutrição
On-line version ISSN 1678-9865
HENRIQUES, Viviana Teixeira et al. Omega-3 fatty acids reduce the development of preneoplasic lesions. Rev. Nutr. [online]. 2009, vol.22, n.2, pp. 237-244. ISSN 1678-9865. http://dx.doi.org/10.1590/S1415-52732009000200006.
OBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.
Keywords : Fatty acids; Precancerous; Dietary supplements.