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Revista de Nutrição

versão impressa ISSN 1415-5273

Resumo

ALVARADO, Cornelio Barrientos et al. Effect of subchronic oral administration of glucosamine in the regulation of body weight, glycemia and dyslipidemia induced hypercholesterolemic Wistar rat. Rev. Nutr. [online]. 2014, vol.27, n.6, pp.689-701. ISSN 1415-5273.  http://dx.doi.org/10.1590/1415-52732014000600004.

Objective:

This study evaluated the effect of oral glucosamine on overweight and dyslipidemia caused by a high-fat diet in rats.

Methods:

Four groups of Wistar rats: fed with commercial rodent food and drinking water without (control group) and with glucosamine (500 mg kg-1 per day) and a high-fat diet enriched with 24% (g/g) butter pork and drinking water without and with glucosamine, for 22 weeks; the body weight, abdominal fat, blood glucose, triglycerides, total cholesterol, and high density lipoprotein in serum were evaluated.

Results:

Body weight gain, increased blood glucose levels and dyslipidemia were observed in the high-fat diet group versus the control group (p<0.001). When glucosamine was administered the same diet the effects were minimized, with a decrease in the amount of abdominal-fat and lipid profile levels in serum (p>0.05), regulated body weight, and high density lipoprotein and glycaemia (p<0.05). The glucosamine did not affect body weight and lipid metabolism in rats when administered with a normal diet.

Conclusions:

Glucosamine regulated the body weight blood glucose and dyslipidemia caused by a high-fat diet, favoring increased high density lipoprotein cholesterol in rats. It did not affect body weight and lipid metabolism when administered with commercial food.

Palavras-chave : Blood glucose; Glucosamine; Cholesterol, HDL; Body weight.

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