Reference |
City where the clinical trial was conducted |
Time of supplement administration |
Vitamin A dosage |
Number of participants |
Results |
Score -Jadad scale |
Puerperium |
Fernandes et al.1919. Fernandes TF, Figueiroa JN, Arruda IKG, Diniz AS. Effect on infant illness of maternal supplementation with 400 000 IU vs 200 000 IU of vitamin A. Pediatrics 2012; 129(4): e960-6. (2012) |
Recife (PE) |
Immediate postpartum (1st dose) and from 8 to 10 days after delivery (2nd dose for G1) |
Retinol palmitate - 400,000 IU (G1) and 200,000 IU (G2) |
276: 134 (G1) and 142 (G2) |
There were no significant differences between treatment groups for assessed child's intercurrences. |
5 |
Santos et al.2120. Santos CS, Kruze I, Fernandes T, Andreto LM, Figueiroa JN, Diniz AS. The effect of a maternal double megadose of vitamin A supplement on serum levels of retinol in children aged under six months. J Nutr Metab 2013; 2013: 876308. (2013) |
Recife (PE) |
Immediate postpartum (1st dose) and 10 days after delivery (2nd dose for G1) |
Retinol palmitate - 400,000 IU (G1) and 200,000 IU (G2) |
173: 81 (G1) and 92 (C) |
There were no differences between groups regarding increase of child retinol contents in the assessed moments. |
5 |
Bezerra et al.1616. Bezerra DS, Araújo KF, Azevêdo GMM, Dimenstein R. A randomized trial evaluating the effect of 2 regimens of maternal vitamin A supplementation on breast milk retinol levels. J Hum Lact 2010; 26: 148-57. (2010) |
Natal (RN) |
Immediate postpartum, with a 24-hour interval between one dose and another in S2 |
Retinol palmitate - 200,000 IU (S1); double dose 200,000 IU with a 24-hour interval (S2) and control (C) |
143: 30 (C); 55 (S1) and 58 (S2) |
There were no significant differences found in retinol contents on colostrum between groups (p > 0.05). In the mature milk, retinol content was significantly different between S1 and C (p > 0.05). |
< 3 |
Martins et al.2021. Martins TM, Ferraz IS, Daneluzzi JC, Martinelli Jr CE, Del Ciampo LA, Ricco RG, et al. Impact of maternal vitamin A supplementation on the mother-infant pair in Brazil. Eur J Clin Nutr 2010; 64(11): 1302-7. (2010) |
Ribeirão Preto (SP) |
Supplementation between the 20th and 30th day after delivery |
Retinol palmitate - 200,000 IU (G1) and soy oil (C) |
61: 31 (G1) and 30 (C) |
Increase of serum retinol contents in the supplemented groups compared with presupplementation and content of control subjects (p = 0.032); difference in the prevalence of vitamin A deficiency in breast milk between groups (p = 0.002). |
< 3 |
Lima et al.1818. Lima MSR, Ribeiro PPC, Medeiros JMS, Silva IF, Medeiros ACP, Dimenstein R. Influence of postpartum supplementation with vitamin A on the levels of immunoglobulin A in human colostrum. J Pediatr (Rio J) 2012; 88(2): 115-8. (2012) |
Natal (RN) |
Immediate postpartum |
Retinol palmitate - 200,00 IU (S) and control (C) |
96: 52 (S1) and 44 (C) |
Increase of sIgA contents on colostrum between S participants compared with C ones (p < 0.00001). |
< 3 |
Ribeiro et al.1717. Ribeiro KDS, Araújo KF, Dimenstein R. Efeito da suplementação com vitamina A sobre a concentração de retinol no colostro de mulheres atendidas em uma maternidade pública. Rev Assoc Med Bras 2009; 55(4): 452-7. (2009) |
Natal (RN) |
Until 16 hours after delivery |
Retinol palmitate - 200,000 IU (S1) and without supplementation (C) |
91: 47 (S1) and 44 (C) |
Increases of retinol contents on colostrum in the S1 24 hours after supplementation (p < 0.0001). Women with lack of retinol on colostrum at 0 h time transferred more retinol to the colostrum in the 24 hours after supplementation. |
< 3 |
Bezerra et al.1212. Bezerra DS, Araújo KF, Azevêdo GMM, Dimenstein R. Suplementação materna com retinil palmitato no pós-parto imediato: consumo potencial por lactentes. Rev Saúde Pública 2009; 43(4): 572-9. (2009) |
Natal (RN) |
Immediate postpartum |
Retinol palmitate - 200,000 IU (S1) and 0 IU (C) |
85: 55 (S1) and 30 (C) |
Increase of retinol contents in breast milk 24 hours and 30 days after supplementation (p < 0.05). |
< 3 |