Revista Brasileira de Plantas Medicinais
versão impressa ISSN 1516-0572
MANETTI, L.M. et al. Evaluation of antimicrobial, cytotoxic, molluscicidal and antioxidant activities of Bromelia antiacantha Bertol. (Bromeliaceae). Rev. bras. plantas med. [online]. 2010, vol.12, n.4, pp. 406-413. ISSN 1516-0572. http://dx.doi.org/10.1590/S1516-05722010000400002.
Bromelia antiacantha Bertol. (Bromeliaceae), popularly known as "gravatá" or "caraguatá", shows medicinal, nutritional and ornamental properties. In the present study, the alcoholic extracts of leaves and fruits of this species were evaluated for antifungal, antibacterial, cytotoxic, molluscicidal and antioxidant activities. The alcoholic extracts evaluated by microdilution method were not efficient against the standard strain of Candida albicans (ATCC 90028), clinical strains of C. albicans and C. glabrata, and S. aureus (ATCC 6538), P. aeruginosa (ATCC 9027) and E. coli (ATCC 8739). The cytotoxic activity evaluated by toxicity bioassay on nauplii of Artemia salina Leach (TAS) was positive for both extracts, with LD50 values ranging around 620 µg mL-1 and 360 µg mL-1 for alcoholic extracts from leaves and fruits, respectively. The molluscicidal activity evaluated against Biomphalaria glabrata (Mollusca, Gastropoda) did not present acute toxicity for 400 µg mL-1 solutions. The antioxidant properties of the extracts investigated in vitro using the DPPH• method were considered modest (~ 35% of inhibition at 1000 µg mL-1). Among the evaluated biological activities, cytotoxic activity was the most marked.
Palavras-chave : Bromeliaceae; Bromelia antiacantha; "caraguatá"; "gravatá"; cytotoxic activity.