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Revista Brasileira de Plantas Medicinais

Print version ISSN 1516-0572

Abstract

ASSINI, F.L.; FABRICIO, E.J.  and  LANG, K.L.. Pharmacological effect of aqueous extract from Solidago chilensis Meyen on mice. Rev. bras. plantas med. [online]. 2013, vol.15, n.1, pp.130-134. ISSN 1516-0572.  http://dx.doi.org/10.1590/S1516-05722013000100018.

Solidago chilensis Meyen (Asteraceae) is a species native to South America (Brazil), found especially in the south region of Brazil, where it is commonly known as "arnica-do-mato". In folk medicine, it has been used as diuretic, healing and anti-inûammatory. In the present study, the pharmacological effects of aqueous extracts from roots of S. chilensis were assessed in vivo in experimental models for antidepressant, anti-inflammatory and locomotor-type activity. The extract (25, 50 and 250 mg kg-1) was administered by the oral route 30 minutes prior to behavioral tests. Results indicate that, at the employed levels, aqueous extract from S. chilensis did not show antidepressant-type activity although it induced significant analgesic and anti-inflammatory effects. A reduction in the locomotor activity was noted at the highest administered level (250 mg kg-1), suggesting an effect on the central nervous system. In conclusion, results agree with the literature about analgesic and anti-inflammatory effects of this plant, also suggesting an activity of S. chilensis extract on the central nervous system. These remarks, however, do not exclude a possible peripheral muscular relaxing effect of the extract.

Keywords : Solidago chilensis analgesia; inflammation; depression; pharmacological activity.

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