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Revista Brasileira de Plantas Medicinais

Print version ISSN 1516-0572

Abstract

SARAIVA, A.M. et al. Antimicrobial and synergic activity of fractions from the leaves of Schinopsis brasiliensis Engl. against Staphylococcus aureus multiresistant clones. Rev. bras. plantas med. [online]. 2013, vol.15, n.2, pp.199-207. ISSN 1516-0572.  http://dx.doi.org/10.1590/S1516-05722013000200006.

The aim of this study was to evaluate the antimicrobial and synergic activity of 4 leaf fractions of Schinopsis brasiliensis Engl (F1', F2', F1" and F2") against multidrug-resistant Staphylococcus aureus strains. The used methods were agar well diffusion, minimum inhibitory concentration (MIC) - agar dilution, and bioautography. The bioautographic results showed three inhibition zones that corresponded to at least four active compounds, two of which (methyl gallate and gallic acid) have already been isolated from leaves. The F2" (200∝g/mL) fraction showed inhibition zones of 16 mm and 19 mm against S. aureus multidrug-resistant and Klebsiella pneumoniae strains and a MIC value of 100∝g/mL, respectively. The analyses of associations of fraction F1" or F2" (25 and 50∝g/mL) with tetracycline and oxacillin showed additive and synergistic action for F2" (50∝g/mL), although it was not enough to decrease the MIC values to less than 2 and 4∝g/mL, necessary to classify the strains as susceptible to oxacillin and tetracycline, respectively. Thus, it was concluded that F2" from the leaves of S. brasiliensis showed antimicrobial potential against multidrug-resistant MRSA strains, and the associations of the fractions with the tested antibiotics showed no benefits, not justifying their concomitant use.

Keywords : Schinopsis brasiliensis; Staphylococcus aureus; Antimicrobial activity; Multidrug-resistant strains.

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