SciELO - Scientific Electronic Library Online

vol.14 issue4Strain hardening behaviour in forming of sintered iron-0.35% carbon powder metallurgy preform during cold upsettingConformational analysis and electronic structure of chiral carbon and carbon nitride nanotubes author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Materials Research

Print version ISSN 1516-1439


TAVARES, Débora dos Santos et al. Incorporation of strontium up to 5 Mol. (%) to hydroxyapatite did not affect its cytocompatibility. Mat. Res. [online]. 2011, vol.14, n.4, pp.456-460.  Epub Oct 28, 2011. ISSN 1516-1439.

The aim of this work was to produce hydroxyapatite (HA) granules containing 0, 0.5, 1 and 5 mol. (%) of strontium (Sr), evaluate the physico-chemical properties and also the cytotoxicity by three different parameters of cell viability (ISO 10993-5, 10993-12). The physico-chemical characterization was carried out by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and X-ray fluorescence (XRF). The XRD profile presented the main peaks of HA (JCPDS 860740) and the absorption bands of HA were identified by FTIR. The XRF results showed that the strontium concentration was close to the theoretical value. Regarding the cytotoxicity assays, the incorporation of strontium up to 5 mol. (%) to the HA did not affected dehydrogenase activity (XTT, 2,3-bis[2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide), membrane integrity (neutral red uptake) or DNA contend (incorporation of crystal violet), in relation to HA alone. In conclusion, hydroxyapatite containing from 0.5 to 5 mol. (%) of Sr was successfully produced and presented no cytotoxicity.

Keywords : strontium; hydroxyapatite; cytotoxicity.

        · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License