Resumo

SIQUEIRA, Lilian et al. Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al₂O₃ Scaffolds Obtained by Gel-Casting of Foams. Mat. Res. [online]. 2017, vol.20, n.4, pp.973-983.  Epub 22-Maio-2017. ISSN 1980-5373.  https://doi.org/10.1590/1980-5373-mr-2016-0467.

Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.

Palavras-chave : Tricalcium phosphate; alumina; gel-casting method; cytocompatibility; scaffolds.

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