PURPOSE:
this study aimed to assess the functioning of the vestibular system of guinea pigs exposed to the organophosphate chlorpyrifos, acutely, through caloric stimulation electronystagmography.
METHODS:
the research conducted an experimental electronystagmography of guinea pigs exposed to organophosphate for 10 consecutive days, at doses 0.5 mg / kg / day and 1.0 mg / kg / day intraperitoneally and compared with a control group that received distilled water administration. We performed caloric ice (10 º C) and compared the variables frequency of appearance of nystagmus in 10 seconds (u / s) and angular velocity of the slow component (º / s).
Results:
the results showed no statistically significant difference in the comparison of variables between groups.
CONCLUSION:
we conclude that the tested doses of the pesticide organophosphate chlorpyrifos caused no detectable functional damage in the caloric test.
Postural Balance; Vestibule; Labyrinth; Insecticides; Organophosphate; Pesticides; Drug Toxicity
