SciELO - Scientific Electronic Library Online

vol.115 número4Upper extremity nerve lesions (diagnosis, indications, surgical techniques)del 11(q23) as a prognostic factor of iron overload in refractory anemia with ringed sideroblasts índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


Sao Paulo Medical Journal

versión impresa ISSN 1516-3180versión On-line ISSN 1806-9460


LIMA, Carmen Silvia Passos; SOUZA, Cármino Antonio de; CARDINALLI, Izilda Aparecida  y  LORAND-METZE, Irene. Lymphoblastic transformation of myelodysplastic syndrome. Sao Paulo Med. J. [online]. 1997, vol.115, n.4, pp.1508-1512. ISSN 1516-3180.

Mielodysplastic syndromes (MDS) are clonal disorders of the hemopoietic stem cell. About one third of the cases terminate in an acute leukemia, usually acute myeloblastic leukemia. However, few cases of transformation into acute lymphoblastic leukemia (ALL) have been described. We present a case of refractory anemia that transformed into ALL two months after diagnosis and was successfully treated with conventional chemotherapy. Two years later a hyperfibrotic form of MDS was detected in the patient, that soon after terminated in acute megakaryoblastic leukemia. The course of MDS in the present case provides evidence that MDS can involve a pluripotent stem cell, presenting clonal evolution, documented by successive changes in its clinical and hematological features.

Palabras clave : Myelodysplastic syndrome; Acute lymphoblastic leukemia; Clonal evolution.

        · resumen en Portugués     · texto en Inglés     · Inglés ( pdf epdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons