Sao Paulo Medical Journal
Print version ISSN 1516-3180
CHAUFFAILLE, Maria de Lourdes L. F. et al. Langerhans cell histiocytosis. Sao Paulo Med. J. [online]. 1998, vol.116, n.1, pp. 1625-1628. ISSN 1516-3180. http://dx.doi.org/10.1590/S1516-31801998000100006.
The authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentine, but the diagnosis was done with the demonstration of Birbeck granules with eletronic mucroscopy. The treatment was based on systemical chemotherapy although vulvar lesion has a bad response to chemotherapy.
Keywords : Histiocytosis X; Langerhans cell; Diabetes insipidus.