Sao Paulo Medical Journal
versión impresa ISSN 1516-3180
versión On-line ISSN 1806-9460
GUIMARAES, Paulo Celso Motta et al. Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension. Sao Paulo Med. J. [online]. 1998, vol.116, n.3, pp.1721-1726. ISSN 1516-3180. http://dx.doi.org/10.1590/S1516-31801998000300006.
OBJECTIVE: To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH). DESIGN: Prospective clinical study, controlled, non randomized and open. LOCATION: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, referral center, university hospital. PARTICIPANTS: 15 patients with recurring stasis ulcer were analyzed, selected randomly from the venous diseases outpatient center, and 4 without lower limb venous alterations were also analyzed. INTERVENTION: Blood samples from the femoral and brachial veins were drawn following supine and 45º reverse Trendelenburg. MAIN OUTCOMES MEASURES: Direct leukocyte count and analysis of the thomboxane B2 with enzyme linked immunosorbent assay test. RESULTS: After 30 minutes in reverse Trendelenburg, patients with CVH showed a leukocyte count reduced by ±27% (p=0.02) and thromboxane B2 levels increased by ±158% (p=0.02). CONCLUSIONS: We suggest that future studies of medications for stasis ulcers include their effects on leukocyte entrapment and thromboxane B2 production in the lower limb venous system.
Palabras clave : Venous ulcers; Venous insufficiency; White blood count; Thromboxane B2.