Sao Paulo Medical Journal
Print version ISSN 1516-3180
On-line version ISSN 1806-9460
MORAES, Aparecida Machado de; ANNICHINO-BIZZACCHI, Joyce Maria and ROSSI, Ana Beatris Rodrigues. Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing. Sao Paulo Med. J. [online]. 1998, vol.116, n.4, pp.1747-1752. ISSN 1516-3180. http://dx.doi.org/10.1590/S1516-31801998000400002.
OBJECTIVE: To evaluate the efficiency of biological sealant, an autologous fibrin glue, in dermatological surgery. DESIGN: Randomized clinical trial. SETTING: The Dermatology Service of Hospital das Clínicas, Universidade de Campinas (UNICAMP), referral center. PATIENTS: 14 patients with malign epithelial cutaneoos tumors participated in the evaluation, each having two tumors, generally facial and symmetrical, in order to perform a comparative evaluation on the same individual. PROCEDURES: The glue was prepared beforehand with a sample of autologous blood. Surgical extirpation of the tumor was followed by grafts or second intention healing. OUTCOMES: The efficiency of the sealant was then evaluated in relation to hemostasis, adhesion, surgical time and evolution of the granulation tissue, clinically and histologically. RESULTS: Immediate hemostasis and graft adhesion, with a significant reduction of surgical time, and in the open wounds there was immediate hemostasis and a clinical increase in granulation tissue, but with no histological differences among the groups on the 7th day. CONCLUSION: It is an adjuvant resource in skin cancer surgery.
Keywords : Fibrin glue; Wound healing; Skin cancer; Dermatologic surgery.