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Sao Paulo Medical Journal

versión impresa ISSN 1516-3180
versión On-line ISSN 1806-9460


ROSSINI, Marta Soares; LORAND-METZE, Irene; OLIVEIRA, Gislaine Borba  y  SOUZA, Cármino Antonio De. Vanishing bile duct syndrome in Hodgkin's disease: case report. Sao Paulo Med. J. [online]. 2000, vol.118, n.5, pp.154-157. ISSN 1516-3180.

CONTEXT: Liver damage is relatively common in patients affected by Hodgkin's disease. A smaller proportion of cases develops jaundice. Recently, the vanishing bile duct syndrome was described in Hodgkin's disease. The mechanisms of this severe complication have been poorly understood until now. OBJECTIVE: To describe a rare case of intra-hepatic cholestasis due to vanishing bile duct syndrome. DESIGN: Case report. CASE REPORT: A 38-year-old male patient affected by Hodgkin's disease. Liver biopsy showed no detectable Hodgkin's disease. Intra-hepatic cholestasis was found and none of the six portal tracts analyzed contained normal bile ducts. The treatment was based on conventional and high-dose escalation chemotherapy. The patient died from an irreversible liver failure while in complete remission from Hodgkin's disease.

Palabras clave : Hodgkin's disease; Vanishing bile duct syndrome; Liver failure.

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