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Sao Paulo Medical Journal

Print version ISSN 1516-3180On-line version ISSN 1806-9460


MICHELETTI, Adilha Misson Rua et al. Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study . Sao Paulo Med. J. [online]. 2005, vol.123, n.5, pp.250-252. ISSN 1516-3180.

CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins. CASE REPORT: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.

Keywords : Angiofibroma; Connective tissue; Mesoderm; Neoplasm; Vulva.

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