SciELO - Scientific Electronic Library Online

 
vol.129 issue5Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trialsCystic brain metastases radiologically simulating neurocysticercosis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Sao Paulo Medical Journal

Print version ISSN 1516-3180

Abstract

MARCHINI, Giovanni Scala et al. Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. Sao Paulo Med. J. [online]. 2011, vol.129, n.5, pp. 346-351. ISSN 1516-3180.  http://dx.doi.org/10.1590/S1516-31802011000500010.

CONTEXT: Synthesis of cortisol and aldosterone is impaired in patients with congenital adrenal hyperplasia (CAH) because of 21-hydroxylase deficiency. Men with CAH have low fertility rates compared with the normal population, and this is related to testicular adrenal rest tumors. Findings of azoospermia in combination with a testicular tumor on ultrasound are likely to have a mechanical cause, especially when in the testicular mediastinum. The preferred treatment method consists of intensive corticoid therapy. However, when the tumor is unresponsive to steroid therapy, surgical treatment should be considered. CASE REPORT: We present the case of a male patient with CAH due to 21-hydroxylase deficiency who presented a testicular tumor and azoospermia. Treatment with low daily corticoid doses had previously been started by an endocrinologist, but after 12 months, no significant change in sperm count was found. Although the adrenocorticotrophic hormone and 17-hydroxyprogesterone levels returned to normal values, the follicle-stimulating hormone (FSH), luteinizing hormone and testosterone levels remained unchanged. Ultrasound examination confirmed that the testicles were small and heterogenous bilaterally, and revealed a mosaic area at the projection of the testis network bilaterally. Magnetic resonance imaging confirmed the finding. Testicular biopsy revealed the presence of preserved spermatogenesis and spermiogenesis in 20% of the seminiferous tubules in the right testicle. The patient underwent testis-sparing tumor resection. After 12 months of follow-up, there was no tumor recurrence but the patient still presented azoospermia and joined an intracytoplasmic sperm injection program.

Keywords : Adrenal hyperplasia, congenital; Adrenal rest tumor; Infertility; Testis; Microsurgery.

        · abstract in Portuguese     · text in English     · pdf in English