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Sao Paulo Medical Journal

Print version ISSN 1516-3180


AGUIAR JUNIOR, Samuel et al. Natural history and surgical treatment of chordoma: a retrospective cohort study. Sao Paulo Med. J. [online]. 2014, vol.132, n.5, pp.297-302.  Epub July 29, 2014. ISSN 1516-3180.


Chordoma is a rare tumor with a high risk of locoregional recurrences. The aim of this study was analyze the long-term results from treating this pathological condition.


Cohort study in a single hospital in São Paulo, Brazil.


This was a retrospective cohort study on 42 patients with chordoma who were treated at Hospital A. C. Camargo between 1980 and 2006. The hospital records were reviewed and a descriptive analysis was performed on the clinical-pathological variables. Survival curves were estimated using the Kaplan-Meier method and these were compared using the log-rank test.


Nineteen patients were men and 23 were women. Twenty-five tumors (59.5%) were located in the sacrum, eleven (26.2%) in the skull base and six (14.3%) in the mobile spine. Surgery was performed on 28 patients (66.7%). The resection was considered to have negative margins in 14 cases and positive margins in 14 cases. The five-year overall survival (OS) was 45.4%. For surgical patients, the five-year OS was 64.3% (82.2% for negative margins and 51.9% for positive margins). In the inoperable group, OS was 37.7% at 24 months and 0% at five years.


Complete resection is related to local control and definitively has a positive impact on long-term survival.

Keywords : Chordoma; Surgical procedures; operative; Recurrence; Survival; Risk factors; Mortality.

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