Andreasson et al.77. Andreasson P, Johansson B, Billström R, et al. Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements. Leukemia. 1998;12(3):390-400.
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F/62 |
Not informed |
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Avet-Loiseau et al.88. Avet-Loiseau H, Godon C, Li JY, et al. Amplification of the 11q23 region in acute myeloid leukemia. Genes Chromosomes Cancer. 1999;26(2):166-70.
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F/53 |
M4 |
Died after diagnosis |
Cigudosa et al.99. Cigudosa JC, Odero MD, Calasanz MJ, et al. De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19. Genes Chromosomes Cancer. 2003;36(4):406-12.
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M/69 F/59 |
Not informed Not informed |
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Dastugue et al.1010. Dastugue N, Lafage-Pochitaloff M, Pagès M P, et al. Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). Blood. 2002;100(2):618-26.
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M/57 |
Not informed |
Died after 5.7 months |
El-Rifai et al.1111. El-Rifai W, Elonen E, Larramendy M, Ruutu T, Knuutila S. Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia. Leukemia. 1997;11(7):958-63.
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F/52 |
M1 |
Still alive |
Fischer et al.1212. Fischer K, Fröhling S, Scherer SW, et al. Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias. Blood. 1997;89(6):2036-41.
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NI |
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Groupe Français de Cytogénétique Hématologique1313. Chromosome analysis of 63 cases of secondary nonlymphoid blood disorders: a cooperative study. Groupe Français de Cytogénétique Hématologique. Cancer Genet Cytogenet. 1984;12(2):95-104.
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F/89 |
Not informed |
Died after 1 month |
Gisselsson et al.1414. Gisselsson D, Höglund M, Mertens F, et al. The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells. Hum Genet. 1999;104(4):315-25.
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M/72 |
M4 |
Not informed |
Johansson et al.1515. Johansson B, Billström R, Kristoffersson U, et al. Deletion of chromosome arm 3p in hematologic malignancies. Leukemia. 1997;11(8):1207-13.
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M/72 |
M4 |
Not informed |
Koka et al.1616. Koka R, Mainor CB, Banerjee A, Baer MR, Zou YS. Concomitant amplification of the MLL gene on a ring chromosome and a homogeneously staining region (hsr) in acute myeloid leukemia: mechanistic implications. Leuk Lymphoma. 2017;58(5):1250-3.
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F/61 |
Not informed |
Died 7 days after treatment |
Lindvall et al.1717. Lindvall C, Nordenskjöld M, Porwit A, Björkholm M, Blennow E. Molecular cytogenetic characterization of acute myeloid leukemia and myelodysplastic syndromes with multiple chromosome rearrangements. Haematologica. 2001;86(11):1158-64.
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F/74 F/61 |
M1 M4 |
Not informed Not informed |
Liozon et al.1818. Liozon E, Brigaudeau C, Trimoreau F, et al. Is treatment with hydroxyurea leukemogenic in patients with essential thrombocythemia? An analysis of three new cases of leukaemic transformation and review of the literature. Hematol Cell Ther. 1997;39(1):11-8.
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M/65 |
M0 |
Died after 6 months |
Mamuris et al.1919. Mamuris Z, Dumont J, Dutrillaux B, Aurias A. Chromosomal differences between acute nonlymphocytic leukemia in patients with prior solid tumors and prior hematologic malignancies. A study of 14 cases with prior breast cancer. Cancer Genet Cytogenet. 1989;42(1):43-50.
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Not informed |
M2 |
Not informed |
Michaux et al.2020. Michaux L, Wlodarska I, Stul M, et al. MLL amplification in myeloid leukemias: A study of 14 cases with multiple copies of 11q23. Genes Chromosomes Cancer. 2000;29(1):40-7.
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F/69 |
M6 |
Not informed |
Mrózek et al.2121. Mrózek K, Heinonen K, Theil KS, Bloomfield CD. Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q. Genes Chromosomes Cancer. 2002;34(2):137-53.
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F/53 |
M4 |
Not informed |
Poppe et al.2222. Poppe B, Vandesompele J, Schoch C, et al. Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies. Blood. 2004;103(1):229-35.
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M/63 M/72 F/46 |
M1 M1 M2 |
Not informed Not informed Not informed |
Sárová et al.2323. Sárová I, Brezinová J, Zemanová Z, et al. Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia. Cancer Genet Cytogenet. 2010;199(2):121-7.
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M/28 |
M2 |
Not informed |
Schoch et al.2424. Schoch C, Haferlach T, Bursch S, et al. Loss of genetic material is more common than gain in acute myeloid leucemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH. Genes Chromosomes Cancer. 2002;35(1):20-9.
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NI NI NI NI NI |
Not informed Not informed Not informed Not informed Not informed |
Not informed Not informed Not informed Not informed Not informed |
Streubel et al.2525. Streubel B, Valent P, Jäger U, et al. Amplification of the MLL gene on double minutes, a homogenously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome. Genes Chromosomes Cancer. 2000;27(4):380-6.
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M/54 |
M4 |
Not informed |
Tanaka et al.2626. Tanaka K, Eguchi M, Eguchi-Ishimae M, et al. Restricted chromosome breakpoint sites on 11q22-q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement. Cancer Genet Cytogenet. 2001;124(1):27-35.
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M/72 |
M2 |
Not informed |
Whang-Peng et al.2727. Whang-Peng J, Lee EC, Kao-Shan CS, Schechter G. Ring chromosome in a case of acute myelomonocytic leukemia: its significance and a review of the literature. Hematol Pathol. 1987;1(1):57-65.
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M/45 |
M4 |
Died after 6 months |
Zatkova et al.2828. Zatkova A, Ullmann R, Rouillard JM, et al. Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients. Genes Chromosomes Cancer. 2004;39(4):263-76.
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M/60 M/50 F/56 M/63 F/76 |
Not informed Not informed M5a M2 M2 |
Not informed Not informed Not informed Not informed Not informed |