Adiponectin2121. de Almeida-Pititto B, Ribeiro-Filho FF, Santos IS, et al. Association between carotid intima-media thickness and adiponectin in participants without diabetes or cardiovascular disease of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Eur J Prev Cardiol. 2017;24(2):116-22.
|
AdjOR for the association with CIMT ≥ 75th percentile for a given age, sex and race: |
Low adiponectin levels were associated with CIMT values in this subgroup, after adjustment for multiple confounders (including body mass index). |
Log-transformed adiponectin: 0.78 (95% CI: 0.63-0.97) |
Ankle-brachial index2222. Miname M, Bensenor IM, Lotufo PA. Different methods of calculating ankle-brachial index in mid-elderly men and women: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Braz J Med Biol Res. 2016;49(12):e5734.
|
Positive likelihood ratios for high CIMT, using: |
Positive likelihood ratios for high CIMT (≥ 75th percentile) were higher when the highest (compared with mean or lowest) ankle systolic BP was used for ankle-brachial index calculation. |
Highest ankle systolic BP: 2.79 (95% CI: 1.50-5.18) |
Mean ankle systolic BP: 2.68 (95% CI: 1.74-4.13) |
Lowest ankle systolic BP: 1.83 (95% CI: 1.42-2.36) |
Negative likelihood ratios for high CIMT, using: |
Negative likelihood ratios for high CIMT (≥ 75th percentile) were similar for all ankle-brachial index calculation strategies. |
Highest ankle systolic BP: 0.99 (95% CI: 0.99-1.00) |
Mean ankle systolic BP: 0.99 (95% CI: 0.98-1.00) |
Lowest ankle systolic BP: 0.98 (95% CI: 0.97-0.99) |
Cognitive performance2323. Suemoto CK, Santos IS, Bittencourt MS, et al. Subclinical carotid artery atherosclerosis and performance on cognitive tests in middle-aged adults: Baseline results from the ELSA-Brasil. Atherosclerosis. 2015;243(2):510-5.
|
AdjB for delayed word recall test score: -0.433 (95% CI: -0.724 to -0.142) |
CIMT values were inversely associated with performance in memory tests. |
Cognitive performance2424. Kemp AH, López SR, Passos VMA, et al. Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study. Biol Psychol. 2016;117:216-24.
|
Significant path coefficients for the indirect path between HRV and the TMT-B via HOMA-IR and CIMT: |
Both insulin resistance and CIMT values mediated the association between heart rate variability and performance in the TMT-B. |
Path coefficient for HRV to HOMA-IR: −0.0942 (P < 0.001) |
Path coefficient for HOMA-IR to CIMT: +0.0340 (P < 0.0001) |
Path coefficient for CIMT to TMT-B: +0.1052 (P < 0.0001) |
Endothelial function2525. Lemos SP, Passos VM, Brant LC, et al. Inconsistent Correlation Between Carotid Artery Intima-Media Thickness and Peripheral Arterial Tonometry: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Medicine (Baltimore). 2015;94(33):e1403.
|
AdjB for the reactive hyperemia index: +0.060 (P = 0.023) |
Endothelial function (according to peripheral arterial tonometry) was inconsistently associated with CIMT. Endothelial dysfunction and CIMT may represent distinct phenomena or different stages of the atherosclerotic process. |
AdjB for the mean basal pulse amplitude: +0.010 (P = 0.221) |
HIV infection2626. Pacheco AG, Grinsztejn B, Fonseca Mde J, et al. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study. PLoS One. 2016;11(7):e0158999.
|
AdjB for HIV group: 0.004 (95% CI: -0.006 to +0.014) |
Comparing ELSA-Brasil data with information from individuals with HIV infection (mostly undergoing combined antiretroviral therapy), CIMT values did not differ between groups after adjustment for sociodemographic variables and cardiovascular risk factors. |
Insulin resistance2727. Santos IS, Bittencourt MS, Goulart AC, et al. Insulin resistance is associated with carotid intima-media thickness in non-diabetic subjects. A cross-sectional analysis of the ELSA-Brasil cohort baseline. Atherosclerosis. 2017;260:34-40.
|
AdjOR for the association with CIMT ≥ 75th percentile for a given age, sex and race: |
There was a direct association between insulin resistance and CIMT values, while glucose levels or glycated hemoglobin were not associated with CIMT in the main models. This raised the hypothesis that a direct effect from insulin on atherosclerosis or insulin-promoted medial hypertrophy may be involved. |
One SD increase in HOMA-IR: 1.10 (95% CI: 1.04-1.17) |
Mental symptoms2828. Santos IS, Goulart AC, Brunoni AR, et al. Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data. Atherosclerosis. 2015;240(2):529-34.
|
OR for the association with CIMT ≥ 75th percentile for a given age, sex and race: |
Intensity and frequency of mental symptoms, along with generalized anxiety disorder and common mental disorder, were associated with higher CIMT values in full models. |
For one SD increase in CIS-R scores: 1.12 (95% CI: 1.06-1.19) |
For common mental disorder disease: 1.22 (95% CI: 1.07-1.38) |
For generalized anxiety disorder: 1.19 (95% CI: 1.01-1.41) |
Migraine2929. Goulart AC, Santos IS, Bittencourt MS, Lotufo PA, Benseñor IM. Migraine and subclinical atherosclerosis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cephalalgia. 2016;36(9):840-8.
|
AdjB for migraine with aura: -0.01 (95% CI: -0.03 to +0.01) |
Migraine, regardless of the presence of aura symptoms, was not associated with CIMT values after adjustment for confounders. |
AdjB for migraine without aura: -0.01 (95% CI: -0.02 to +0.01) |
Socioeconomic mobility3030. Guimarães JM, Clarke P, Tate D, et al. Social mobility and subclinical atherosclerosis in a middle-income country: Association of intra- and inter-generational social mobility with carotid intima-media thickness in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Soc Sci Med. 2016;169:9-17.
|
AdjB for downward intergenerational mobility (3 or more levels in a 7-level ladder): +0.013 (P = 0.04) |
Downward intergenerational mobility was associated with higher CIMT values, and the more intense the downward mobility was, the more intense this association also was. For intragenerational mobility, individuals with stable low social status had higher CIMT values than did those with stable high social status. |
AdjB for stable low social status: +0.012 (P = 0.03) |
Socioeconomic status3131. Camelo LV, Giatti L, Chor D, et al. Associations of life course socioeconomic position and job stress with carotid intima-media thickness. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Soc Sci Med. 2015;141:91-9.
|
AdjB for low life course socioeconomic position: |
CIMT values were positively associated with more prolonged exposure to low socioeconomic status (cumulative lifetime socioeconomic position). |
Men: +0.049 (95% CI: +0.020 to +0.079) |
Women: +0.031 (95% CI: +0.001 to +0.063) |
Subclinical hypothyroidism3232. Peixoto de Miranda ÉJ, Bittencourt MS, Pereira AC, et al. Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Nutr Metab Cardiovasc Dis. 2016;26(10):915-21.
|
AdjB for subclinical hypothyroidism: +0.010 (95% CI: +0.001 to +0.019) |
Subclinical hypothyroidism was associated with CIMT values after adjustment for major confounders. |
AdjOR for the association with CIMT ≥ 75th percentile for a given age, sex and race: |
Subclinical hypothyroidism: 1.30 (95% CI: 1.06-1.59) |