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Revista Brasileira de Psiquiatria
On-line version ISSN 1809-452X
LIMA, Ivanor Velloso Meira. Repetições CAG: candidatos na gênese das psicoses funcionais. Rev. Bras. Psiquiatr. [online]. 1999, vol.21, suppl.2, pp. 23-26. ISSN 1809-452X. http://dx.doi.org/10.1590/S1516-44461999000600007.
The author comments about the DNA instability associated with CNS's diseases which display genetic anticipation. He reviews the evidence of anticipation in bipolar and schizophrenia families. He also presents the RED (Repeat Expansion Detection) investigations and screenings with the antibody 1C2 which demonstrated the participation of this mutational mechanism on the functional psychosis genesis.
Keywords : Genetics of psychosis; CAG repeats; anticipation; unstable DNA.