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vol.23 suppl.2Aspectos neuroquímicos: o papel da serotonina no TOCAspectos neurorradiológicos do transtorno obsessivo-compulsivo: o papel dos gânglios da base author indexsubject indexarticles search
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Brazilian Journal of Psychiatry

Print version ISSN 1516-4446On-line version ISSN 1809-452X

Abstract

GONZALEZ, Christina H. Aspectos genéticos do transtorno obsessivo-compulsivo. Rev. Bras. Psiquiatr. [online]. 2001, vol.23, suppl.2, pp.38-41. ISSN 1516-4446.  http://dx.doi.org/10.1590/S1516-44462001000600012.

Since the first descriptions of obsessive-compulsive disorder (OCD), genetic factors have been implicated in the etiology of the illness. Twin studies show a high concordance rate for monozygotic twins. Family studies found a higher risk for OCD among relatives of OCD patients. Segregation analysis studies suggest the possible role of a major effect gene in the etiology of OCD. Association studies using molecular techniques have been conducted to try to find a specific gene or polymorphism involved in OCD. This review outlines the evidence gathered to date, including the recent findings in the molecular genetics analysis.

Keywords : Obsessive-compulsive disorder; Etiology; Genetics; Genetic predisposition to disease.

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