Revista Brasileira de Psiquiatria
On-line version ISSN 1809-452X
VALENTE JR., Antonio Augusto and BUSATTO FILHO, Geraldo. Aspectos neurorradiológicos do transtorno obsessivo-compulsivo: o papel dos gânglios da base. Rev. Bras. Psiquiatr. [online]. 2001, vol.23, suppl.2, pp. 42-45. ISSN 1809-452X. http://dx.doi.org/10.1590/S1516-44462001000600013.
Contemporary neuroanatomical models for obsessive-compulsive disorder (OCD) propose that abnormalities of specific cortico-subcortical circuits mediate the disorder's symptoms. This paper focuses on the basal ganglia, believed to play a critical role in the functioning of those brain circuits. Clinical and experimental studies investigating the presence of abnormalities of basal ganglia structures in OCD are reviewed, with particular emphasis on the neuroimaging literature. Despite controversies in the area, a considerable amount of data has accumulated suggesting that abnormalities of the caudate and putamen nuclei can be associated with OCD. These abnormalities may be particularly relevant to specific subtypes of the disorder, such as early-onset OCD. With the continuing sophistication of neuroimaging technologies, future studies may be able to further clarify the role of each basal ganglia component in the pathophysiology of the various clinical features of OCD.
Keywords : Obsessive-compulsive disorder; Neuroanatomy; Diagnostic imaging; Basal ganglia.