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Revista Brasileira de Psiquiatria

versión impresa ISSN 1516-4446versión On-line ISSN 1809-452X


GAZALLE, Fernando Kratz et al. Polypharmacy and suicide attempts in bipolar disorder. Rev. Bras. Psiquiatr. [online]. 2007, vol.29, n.1, pp.35-38.  Epub 14-Nov-2006. ISSN 1516-4446.

OBJECTIVE: The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder. METHOD: One hundred sixty-nine bipolar disorder outpatients diagnosed using the DSM-IV Structured Clinical Interview were included. Demographic and socioeconomic data, number of medications currently in use, history of suicide attempts, number of years undiagnosed, age of onset and current psychiatric co-morbidities were assessed using a structured questionnaire and DSM-IV criteria. The main outcome measure was the number of psychotropic drugs currently in use. RESULTS: Approximately half of all patients (48.5%) presented a history of suicide attempt; 84% were using more than one medication, and 19% were using more than three drugs. The most frequent combinations of drugs used by these patients were: lithium + valproate (17%); lithium + antipsychotics (10%); lithium + valproate + antipsychotics (9%); and antidepressants + any drug (6%). The number of suicide attempts was associated with the use of multiple drugs. CONCLUSIONS: Our findings support the notion that the use of combination therapy in bipolar disorder may be related to severity of the BD, such as number of suicide attempts.

Palabras clave : Bipolar disorder; Suicide; Polypharmacy; Suicide, attempt; Mood disorder.

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