Revista Brasileira de Psiquiatria
On-line version ISSN 1809-452X
MAIA, Carlos Renato Moreira and ROHDE, Luis Augusto. Pharmacotherapy for the treatment of anxiety disorders in children and adolescents: a sistematic review. Rev. Bras. Psiquiatr. [online]. 2007, vol.29, n.1, pp. 72-79. Epub Nov 14, 2006. ISSN 1809-452X. http://dx.doi.org/10.1590/S1516-44462006005000019.
Anxiety disorders are very prevalent in children and adolescents, causing serious impairments. The pharmacological treatment for these disorders is not much investigated in children and adolescents. Thus, there is no consensus about its indication. The present study aims to check the efficacy and tolerability of drugs used for the treatment of anxiety disorders in children and adolescents in the context of evidence based medicine. A systematic literature review was carried out in the main databases. In addition, authors were contacted. We found seven studies classified as A or B according to criteria established by the Cochrane Collaboration. Findings suggest efficacy for selective serotonin reuptake inhibitors, insignificant or unfavorable results for benzodiazepines and imipramine. Some studies present methodological problems. Methodological improvements are needed in futures clinical trials.
Keywords : Mental disorders diagnosed in childhood; Anxiety disorders; Serotonin uptake inhibitors; Antidepressive agents; Psychopharmacology.