SciELO - Scientific Electronic Library Online

 
vol.33 número1O tratamento farmacológico do transtorno bipolar: uma revisão sistemática e crítica dos aspectos metodológicos dos estudos clínicos modernosAntidepressivos sedativos e insônia índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista Brasileira de Psiquiatria

versão impressa ISSN 1516-4446

Resumo

PORTUGAL, Maria da Glória; MARINHO, Valeska  e  LAKS, Jerson. Pharmacological treatment of frontotemporal lobar degeneration: systematic review. Rev. Bras. Psiquiatr. [online]. 2011, vol.33, n.1, pp. 81-90. ISSN 1516-4446.  http://dx.doi.org/10.1590/S1516-44462011000100016.

OBJECTIVE: To identify the therapeutic options available for treatment of cognitive and behavioral symptoms in frontotemporal lobar degeneration. METHOD: Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal dementia" OR "fronto-temporal dementia" OR "fronto-temporal degeneration" OR "Pick's disease" OR "Pick's atrophy" OR "semantic dementia" OR "progressive aphasia" AND "pharmacotherapy" OR "treatment" OR "efficacy" OR "effects" OR "management" was performed in the Medline and Lilacs databases. Selection criteria: Quality A - randomized clinical trials. Quality B - open studies or reports of six or more cases. Quality C - reports of five or fewer cases. Two reviewers independently assessed the clinical studies. Information collected included diagnostic criteria used, sample size, duration, efficacy and tolerability measures used and results obtained. RESULTS: From the 532 studies found, 29 complied with the inclusion criteria. All studies worked with a small sample, had short duration of treatment and used non-uniform measures in evaluating efficacy and tolerability. Studies showed disparate results with respect to behavior and cognition. CONCLUSION: There is still little, and poor, evidence available for treatment of frontotemporal lobar degeneration and studies with better methodological background are needed.

Palavras-chave : Frontotemporal dementia; Pick's disease; Therapeutics; Review; Frontotemporal lobar degeneration.

        · resumo em Português     · texto em Inglês     · pdf em Inglês