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Brazilian Journal of Psychiatry

versão impressa ISSN 1516-4446


BARBOSA, Izabela G. et al. Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania. Rev. Bras. Psiquiatr. [online]. 2014, vol.36, n.4, pp.340-343.  Epub 29-Jul-2014. ISSN 1516-4446.


To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).


Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).


BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.


These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

Palavras-chave : Neurotrophin; mania; depression; bipolar disorder; biomarker.

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