SciELO - Scientific Electronic Library Online

 
vol.36 número4Factor structure of the Positive and Negative Syndrome Scale (PANSS) in Brazil: convergent validation of the Brazilian versionThe link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Brazilian Journal of Psychiatry

versão impressa ISSN 1516-4446

Resumo

BARBOSA, Izabela G. et al. Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania. Rev. Bras. Psiquiatr. [online]. 2014, vol.36, n.4, pp.340-343.  Epub 29-Jul-2014. ISSN 1516-4446.  https://doi.org/10.1590/1516-4446-2014-1380.

Objective:

To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).

Methods:

Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).

Results:

BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.

Conclusion:

These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

Palavras-chave : Neurotrophin; mania; depression; bipolar disorder; biomarker.

        · texto em Inglês     · Inglês ( pdf )