Dawson2222. Dawson E. Identification of a highly polymorphic triplet repeat marker for the brain cannabinoid receptor gene: use in linkage and association studies of schizophrenia. Schizophr Res. 1995;15:37.
|
1995 |
SCZ |
Multiplex SCZ pedigrees (23)SCZ patients (131)Controls (103) |
Caucasian |
(AAT)n |
(-) |
Tsai2323. Tsai SJ, Wang YC, Hong CJ. Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. Psychiatr Genet. 2000;10:149-51.
|
2000 |
SCZ |
SCZ patients (127) Controls (146) |
Han Chinese |
(AAT)n |
(-) |
Leroy2424. Leroy S, Griffon N, Bourdel MC, Olie JP, Poirier MF, Krebs MO. Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. Am J Med Genet. 2001;105:749-52.
|
2001 |
SCZ; substance abuse; treatment response |
SCZ patients (102) Controls (63) |
French |
rs1049353 |
(+) for substance abuse in patients |
Krebs2525. Krebs MO, Leroy S, Duaux E, Bourdel MC, Griffon N, Laqueille X, et al. Vulnerability to cannabis, schizophrenia and the (ATT)N polymorphism of the cannabinoid receptor type 1 (CNR1) gene. Schizophr Res. 2002;53:72.
|
2002 |
SCZ; cannabis abuse |
SCZ cannabis (102) Non-SCZ cannabis (85) Controls (89) |
French |
(AAT)n |
(+) for cannabis-sensitive SCZ patients |
Ujike1616. Ujike H, Takaki M, Nakata K, Tanaka Y, Takeda T, Kodama M, et al. CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia. Mol Psychiatry. 2002;7:515-8.
|
2002 |
SCZ; SCZ subcategories |
SCZ patients (121) Controls (148) |
Japanese |
(AAT)n rs1049353 |
(+) (AAT)n for hebephrenic SCZ |
Martinez-Gras2626. Martinez-Gras I. Relationship between symptom dimension, neurocognitive functioning and CNR1 central cannabinoid receptor gene with susceptibility to schizophrenia and substance abuse. Eur Neuropsychopharmacol. 2005;15:S579-S80.
|
2005 |
Substance abuse; PANSS scores; WCST (executive function) |
SCZ patients (75 substance abusers/58 non-abusers) (133) |
Spanish |
(AAT)n |
(+) for negative PANSS scale and WCST in substance abusers |
Ballon1717. Ballon N, Leroy S, Roy C, Bourdel MC, Charles-Nicolas A, Krebs MO, et al. (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Pharmacogenomics J. 2006;6:126-30.
|
2006 |
SCZ; cocaine addiction |
SCZ cocaine (45) Non-SCZ cocaine (97) Controls (88) |
African-Caribbean |
(AAT)n |
(+) for cocaine addiction |
Martinez-Gras55. Henquet C, Krabbendam L, Spauwen J, Kaplan C, Lieb R, Wittchen HU, et al. Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. BMJ. 2005;330:11.
|
2006 |
SCZ; substance abuse |
SCZ patients (113) Controls (111) |
Spanish |
(AAT)n |
(+) for schizophrenia |
Seifert2727. Seifert J, Ossege S, Emrich HM, Schneider U, Stuhrmann M. No association of CNR1 gene variations with susceptibility to schizophrenia. Neurosci Lett. 2007;426:29-33.
|
2007 |
SCZ |
SCZ patients (104) Controls (140) |
German |
(AAT)n rs1049353 rs6454674 |
(-) |
Zammit2828. Zammit S, Spurlock G, Williams H, Norton N, Williams N, O'Donovan MC, et al. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br J Psychiatry. 2007;191:402-7.
|
2007 |
SCZ; cannabis use; other phenotype characteristics |
SCZ patients (797) Controls (688) |
UK |
rs1049353 |
(-) |
Chavarria-Siles2929. Chavarria-Siles I, Contreras-Rojas J, Hare E, Walss-Bass C, Quezada P, Dassori A, et al. Cannabinoid receptor 1 gene (CNR1) and susceptibility to a quantitative phenotype for hebephrenic schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2008;147:279-84.
|
2008 |
SCZ; SCZ subcategories |
SCZ patients (244) SCZ relatives (481) |
Costa Rica |
(AAT)n |
(+) for hebephrenic SCZ |
Hamdani1818. Hamdani N, Tabeze JP, Ramoz N, Ades J, Hamon M, Sarfati Y, et al. The CNR1 gene as a pharmacogenetic factor for antipsychotics rather than a susceptibility gene for schizophrenia. Eur Neuropsychopharmacol. 2008;18:34-40.
|
2008 |
SCZ; cannabis use; treatment response |
SCZ patients (133) Controls (141) |
French |
rs806468 rs1049353 rs806379 rs806380 |
(+) rs1049353 for treatment response |
Monteleone3030. Monteleone P, Milano W, Petrella C, Canestrelli B, Maj M. Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain. J Clin Psychopharmacol. 2010;30:441-5.
|
2010 |
SCZ; weight gain |
SCZ patients (83) Controls (80) |
Italian |
rs1049353 |
(-) |
Tiwari1919. Tiwari AK, Zai CC, Likhodi O, Lisker A, Singh D, Souza RP, et al. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology. 2010;35:1315-24.
|
2010 |
Weight gain |
SCZ patients (183) |
German/U.S. |
rs806368 rs1272071 rs1049353 rs806369 rs806370 rs806374 rs806375 rs806377 rs806378 rs2023239 rs806380 rs806381 rs7752758 rs12528858 rs12205430 rs6914429 rs2180619 rs754387 rs9450902 rs10485170 |
(+) rs806378 in patients of European ancestry treated with clozapine or olanzapine |
Ho3131. Ho BC, Wassink TH, Ziebell S, Andreasen NC. Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res. 2011;128:66-75.
|
2011 |
Cannabis abuse; MRI; neurocognitive assessment |
SCZ patients (235) |
U.S. |
rs806365 rs7766029 rs806366 rs806368 rs12710071 rs1049353 rs806374 rs806375 rs806376 rs6454672 rs9450898 rs806380 |
(+) rs7766029/rs12720071/rs9450898 for MRI findings |
Park3232. Park YM, Choi JE, Kang SG, Koo SH, Kim L, Geum D, et al. Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain. Hum Psychopharmacol. 2011;26:332-7.
|
2011 |
Weight gain (olanzapine) |
SCZ patients (78) |
Korean |
rs806368 rs4707436 rs1049353 |
(-) |
van Winkel3333. van Winkel R; Genetic Risk and Outcome of Psychosis (GROUP) Investigators. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. Arch Gen Psychiatry. 2011;68:148-57.
|
2011 |
Psychosis; positive schizotypy; cannabis use |
Patients with psychosis (801)Unaffected siblings (740) |
Netherlands and Belgium |
rs2023239 rs806379 rs1535255 rs6454674 rs806308 rs806377 rs1049353 rs6928499 |
(-) |
Schennach3434. Schennach R, Zill P, Obermeier M, Hauer D, Dehning S, Cerovecki A, et al. The CNR1 gene in depression and schizophrenia - is there an association with early improvement and response? Psychiatry Res. 2012;196:160.
|
2012 |
Treatment response |
SCZ patients (274) Controls (427) |
German |
rs1049353 |
(-) |
Tiwari3535. Tiwari AK, Zai CC, Likhodi O, Voineskos AN, Meltzer HY, Lieberman JA, et al. Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia. Pharmacogenomics J. 2012;12:260-6.
|
2012 |
TD |
SCZ patients (191) |
U.S./Canadian |
rs806369 rs1272071 rs1049353 rs806369 rs806370 rs806374 rs806375 rs806377 rs806378 rs2023239 rs806380 rs806381 rs7752758 rs12528858 rs12205430 rs6914429 rs2180619 rs754387 rs9450902 rs10485170 |
(+) rs806374 |
Costa3636. Costa M, Squassina A, Congiu D, Chillotti C, Niola P, Galderisi S, et al. Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-alpha gene (PPARA) and schizophrenia. Eur Neuropsychopharmacol. 2013;23:749-59.
|
2013 |
SCZ |
SCZ patients (170) Controls (350) |
Italian |
rs1049353 rs7766029 rs806366 rs12720071 rs806380 rs9450898 rs806375 rs806368 rs6454672 rs806374 rs806365 rs806376 |
(-) |
Yu3737. Yu W, De Hert M, Moons T, Claes SJ, Correll CU, van Winkel R. CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia. J Clin Psychopharmacol. 2013;33:186-92.
|
2013 |
MetS |
SCZ patients (407) |
Belgium |
rs6454674 rs6928499 rs806379 rs1535355 rs806377 rs1049353 rs2023239 |
(+) rs6928499 rs1535355 rs2023239 |
Bae2121. Bae JS, Kim JY, Park BL, Kim JH, Kim B, Park CS, et al. Genetic association analysis of CNR1 and CNR2 polymorphisms with schizophrenia in a Korean population. Psychiatr Genet. 2014;24:225-9.
|
2014 |
SCZ |
SCZ patients (337) Controls (394) |
Korean |
rs806376 rs806368 rs806366 rs6689530 rs34570472 |
(-) |
Copoglu3838. Copoglu US, Igci M, Bozgeyik E, Kokacya MH, Igci YZ, Ozden A, et al. Cannabinoid receptor 1 (cnr1) gene polymorphisms in schizophrenia patients: Rs6454674 polymorphism is associated with disease severity. Klinik Psikofarmakol Bülteni. 2015;25:341-7.
|
2015 |
SCZ; symptoms |
SCZ patients (66) Controls (65) |
Turkish |
rs6454674 rs806368 rs1049353 |
(+) rs6454674 for SCZ symptoms |
Suárez-Pinilla3939. Suárez-Pinilla P, Roiz-Santianez R, Ortiz-García de la Foz V, Guest PC, Ayesa-Arriola R, Cordova-Palomera A, et al. Brain structural and clinical changes after first episode psychosis: focus on cannabinoid receptor 1 polymorphisms. Psychiatry Res. 2015;233:112-9.
|
2015 |
Cannabis use; MRI; BMI; clinical psychopathology |
First-episode psychosis patients (65) |
Spanish |
rs1049353 rs1535255 rs2023239 |
(+) all SNPs for MRI and clinical psychopathology |