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Revista Brasileira de Hematologia e Hemoterapia
On-line version ISSN 1806-0870
PAULA, Erich V. de et al. Several opportunistic infections in a young patient with chronic lymphocytic leukemia treated with cladribine. Rev. Bras. Hematol. Hemoter. [online]. 2000, vol.22, n.3, pp. 420-423. ISSN 1806-0870. http://dx.doi.org/10.1590/S1516-84842000000300009.
Hypogamaglobulinemia is frequently associated with B-CLL rendering the patients prone to bacterial infections. The use of purine analogs that cause depletion of T lymphocytes in the treatment of this disease, increases the spectrum of susceptibility of these patients to oportunistic agents. We report a case of a young B-CLL patient treated with 2-CdA, who presented multiple infectious complications during the course of his disease associated with a severe cellular immune deficiency.
Keywords : Chronic lymphocityc leukemia; cryptococcal meningitis; cladribine.