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Revista Brasileira de Hematologia e Hemoterapia

Print version ISSN 1516-8484On-line version ISSN 1806-0870


LONGHI, Fernanda; LAKS, Dani  and  KALIL, Nelson G.N.. Heparin-induced thrombocytopenia. Rev. Bras. Hematol. Hemoter. [online]. 2001, vol.23, n.2, pp.93-99. ISSN 1806-0870.

The aim of this paper is to review current information about the clinical manifestations, diagnosis and management of heparin-induced thrombocytopenia. This was achieved by a bibliographic review using Public Medline and consulting Hematology textbooks. From this study we concluded that heparin-induced thrombocytopenia is a common complication of patients exposed to heparin therapy regardless of underlying conditions. Potentially fatal thrombotic complications have been reported. Therefore, if heparin-induced thrombocytopenia is suspected, an adequate approach including early heparin discontinuation is mandatory. Alternative products for heparin include hirudin and danaparoid sodium. Low-molecular-weight heparin is contraindicated.

Keywords : Thrombocytopenia; heparin; clinical manifestations; therapy; hirudin; danaparoid sodium.

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