Revista Brasileira de Hematologia e Hemoterapia
Print version ISSN 1516-8484
On-line version ISSN 1806-0870
SOUZA, Geane F. de et al. Seroprevalence and immunophenotypic profile of T lymphocyte cells in human T lymphotropic virus seropositive individuals. Rev. Bras. Hematol. Hemoter. [online]. 2003, vol.25, n.1, pp.33-38. ISSN 1516-8484. http://dx.doi.org/10.1590/S1516-84842003000100006.
Human T lymphotropic virus (HTLV) can be transmitted by transfusions of cellular blood products, shared use of contaminated syringes, breast feeding and sexual intercourse. The prevalence of the infection varies according to geographic region, racial group, and population under risk. About 1% to 4% of the infected individuals develop some form of infection-related disease. The association of HTLV-I with Adult T-Cell Leukaemia, as well as the Tropical Spastic Paraparesis, is presently well recognised. Although most HTLV-I-infected individuals remain asymptomatic, there are indications that cellular immune responses are functionally impaired. The aims of this study were to determine the prevalence of HTLV-I/II seropositivity among blood donors in HEMOCE and analyse the immunophenotypic profile of peripheral lymphocytes in 26 HTLV-I seronegative blood donors, 11 symptomatic and 24 asymptomatic HTLV-I soropositive individuals. The prevalence of HTLV-I/II was 0,66%. In the infected group a predominance of females was observed as well as a higher average age. The mean hemoglobin value was found to be significantly lower in this group and the mean polymorphonuclear neutrophil count was significantly higher among the symptomatic individuals. The mean lymphocyte and platelet count were not significantly different between the groups. Immunophenotyping evaluation revealed that the mean CD3+, CD4+, CD8+ T cell counts, as well as the CD4+/CD8+ ratio were not significantly different between the groups. A slightly higher mean CD8+ T lymphocyte count was observed in the seropositive individuals, although it did not reach statistical significance. The activation of CD8+ subset is known to be part of pathogenesis of HTLV-I-related diseases. The predictive value of this immunological finding needs further and long-range studies.
Keywords : Seroprevalence; HTLV-I/II; T lymphocytes; immunophenotyping.