Revista Brasileira de Hematologia e Hemoterapia
versão impressa ISSN 1516-8484
versão On-line ISSN 1806-0870
PEREIRA, Juliana; PEDROSO-MEIRELES, Ana Luísa L.; GODOY, Carla R. T. e CHAMONE, Dalton A. F.. The role of endothelial cells in hematologic malignancies. Rev. Bras. Hematol. Hemoter. [online]. 2008, vol.30, n.3, pp.223-228. ISSN 1516-8484. http://dx.doi.org/10.1590/S1516-84842008000300012.
Vascular neoformation is an essential event in the development of the human body. In this phase vascular networks undergo expansion. Mature endothelial cells constitute the structure of vessel walls so endothelial cells from bone marrow migrate to sites of vascular neoformation with subsequent differentiation as mature endothelial cells (endothelial progenitor cells). Physiopathological and pathological processes such as cancer use angiogenesis as an important component for growth. Studies correlate angiogenesis with aggressive tumors for some types of tumors, including hematological malignancies, thereby highlighting the importance of anti-angiogenic therapy.
Palavras-chave : Angiogenesis; endothelial cell; hematologic malignancies.