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Revista Brasileira de Hematologia e Hemoterapia

versão impressa ISSN 1516-8484versão On-line ISSN 1806-0870

Resumo

OLIVEIRA, Maria Christina L. A. et al. Non-Hodgkin's lymphoma in children with immunodeficiency: report of five cases. Rev. Bras. Hematol. Hemoter. [online]. 2008, vol.30, n.3, pp.249-252. ISSN 1516-8484.  http://dx.doi.org/10.1590/S1516-84842008000300015.

The outcomes of five children with non-Hodgkin's lymphomas associated with immunodeficiency or immunosuppression is reported: three children with HIV, one with primary immunodeficiency and one after liver transplantation. According to the REAL classification, two patients had precursor B-lymphoblastic lymphomas, one had an anaplastic large cell lymphoma, one had a peripheral B-cell neoplasm suggestive of Burkitt's lymphoma, and one had precursor T-lymphoblastic lymphoma. All patients received chemotherapy. Two are in complete remission, two died and one remains under treatment. There has been an increasing awareness of the risk of non-Hodgkin's lymphoma and lymphoproliferative disorders after active antiretroviral therapy and with the expansion of solid organ transplant programs in the pediatric setting. Thus, for these patients it is important to establish risk factors for hematological disorders and determine the optimal and safest treatment.

Palavras-chave : Non-Hodgkin's lymphoma; immunodeficiency; AIDS; hepatic transplant.

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