SciELO - Scientific Electronic Library Online

 
vol.31 número6Análise retrospectiva dos pacientes infectados por RSV na unidade de transplante de medula ósseaA prática transfusional e a formação dos profissionais de saúde índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Revista Brasileira de Hematologia e Hemoterapia

versão impressa ISSN 1516-8484

Resumo

SILVA, Lilianne B.; GONCALVES, Romélia P.  e  MARTINS, Michele F.. Study of the correlation between fetal hemoglobin levels and the prognosis of patients with sickle cell anemia. Rev. Bras. Hematol. Hemoter. [online]. 2009, vol.31, n.6, pp.417-420.  Epub 27-Nov-2009. ISSN 1516-8484.  http://dx.doi.org/10.1590/S1516-84842009005000084.

The fetal hemoglobin (HbF) levels of 47 patients with sickle cell anemia living in Fortaleza, Brazil were analyzed to provide information on the influence of HbF on the prognosis of this disease. Measurement of hematological variables was achieved using a Sysmex KX-21N cell counter ( Roche) and the levels of HbF were determined by the alkali denaturation technique. With increased levels of HbF, there was a trend that fewer patients had painful episodes (p = 0.0405) and leg ulcers (p = 0.0076). There were no statistically significant differences between the levels of HbF and the concentrations of red blood cells, hemoglobin, hematocrit, leukocytes and platelets. The results show that levels of fetal hemoglobin can be used as a prognostic factor in patients with sickle cell anemia however they should not be the only diagnostic tool to predict the clinical status of these patients.

Palavras-chave : Sickle cell anemia; Fetal hemoglobin; prognosis.

        · resumo em Português     · texto em Português     · Português ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons