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Revista Brasileira de Hematologia e Hemoterapia

versão impressa ISSN 1516-8484

Resumo

FERREIRA, Cláudia Natália; SOUSA, Marinez de Oliveira; DUSSE, Luci Maria Sant'Ana  e  CARVALHO, Maria das Graças. A cell-based model of coagulation and its implications. Rev. Bras. Hematol. Hemoter. [online]. 2010, vol.32, n.5, pp.416-421. ISSN 1516-8484.  https://doi.org/10.1590/S1516-84842010000500016.

The concept of a coagulation cascade describes the biochemical interactions of the coagulation factors, but it is flawed as a model of the in vivo hemostatic process. Hemostasis requires both platelet and fibrin plug formation at the site of vessel injury and that the procoagulant substances activated in this process remain at the site of injury. This control of blood coagulation is accomplished as the procoagulant reactions only exist on specific cell surfaces to keep coagulation from spreading throughout the vascular system. A model of coagulation that better explains bleeding and thrombosis in vivo created after considering the critical role of cells. The cellbased model of hemostasis replaces the traditional "cascade" hypothesis, and proposes that coagulation takes place on different cell surfaces in four overlapping steps: initiation, amplification, propagation and termination. The cell-based model allows a more thorough understanding of how hemostasis works in vivo, and sheds light on the pathophysiological mechanism for certain coagulation disorder.

Palavras-chave : Blood coagulation; Blood coagulation factors; Blood coagulation disorders [physiopathology]; Blood platelets [metabolism]; Hemostasis; Thromboplastin; Protein C; Protein S; Antithrombins; Anticoagulants.

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