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Revista Brasileira de Hematologia e Hemoterapia

versão impressa ISSN 1516-8484

Resumo

COELHO, Maria José Dantas et al. Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank. Rev. Bras. Hematol. Hemoter. [online]. 2011, vol.33, n.2, pp.110-114. ISSN 1516-8484.  http://dx.doi.org/10.5581/1516-8484.20110030.

BACKGROUND: The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways. OBJECTIVE: To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law. METHODS: Whole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additionally a leukocyte count was done only on day 1 and microbiological tests on day 5 of storage. Collagen and adenosine diphosphate were used as inducing agonists for platelet aggregation testing. RESULTS: Donor whole blood had normal aggregation (aggregation with adenosine diphosphate = 67% and with collagen = 78%). The median aggregation in platelet concentrates with adenosine diphosphate was low throughout storage (18% on day 1, 7% on day 3 and 6% on day 5) and the median aggregation with collagen was normal only on day 1 and low thereafter (54.4% on day 1, 20.5% on day 3 and 9% on day 5). CONCLUSION: Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy.

Palavras-chave : Hemostasis; Quality control; Collagen; Blood component transfusion; Blood banks; Platelet aggregation.

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