Revista Brasileira de Hematologia e Hemoterapia
Print version ISSN 1516-8484
CARVALHO, Daiana Landenberger de; BARBOSA, Cristian Dias; CARVALHO, André Luiz de and BECK, Sandra Trevisan. Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome. Rev. Bras. Hematol. Hemoter. [online]. 2012, vol.34, n.4, pp.280-284. ISSN 1516-8484. http://dx.doi.org/10.5581/1516-8484.20120072.
OBJECTIVE: This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients. METHODS: Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME). RESULTS: Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3. CONCLUSION: The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.
Keywords : HLA antigens; Fusion proteins, BCR-ABL; Genetic predisposition to disease; Philadelphia chromosome; Leukemia, myelogenous, chronic, BCR-ABL positive; Precursor cell lymphoblastic leukemia-lymphoma.